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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Quinaldine Derivatives: Preparation and Biological Activity

Author(s): J. Jampilek, M. Dolezal, J. Kunes, V. Buchta, L. Silva and K. Kralova

Volume 1, Issue 6, 2005

Page: [591 - 599] Pages: 9

DOI: 10.2174/157340605774598108

Price: $65


The series of quinaldine derivatives were prepared, some of them by means of novel synthetic methods. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. The prepared compounds were tested for their in vitro antifungal activity as well as for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.) and the reduction of chlorophyll content in Chlorella vulgaris Beij.). Structure-activity relationships among the chemical structure, the physical properties and the biological activities of the evaluated compounds are discussed in the article.

Keywords: quinaldine derivatives, in vitro antifungal activity, photosynthesis inhibition, lipophilicity, structure-activity relationships, chlorella vulgaris, spinach chloroplasts

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