Abstract
1,2,4-Thiadiazole is a distinctive class of small heterocyclic thiol trapping agents that serve as an interesting pharmacophore in the design of inhibitors targeting the cysteine residues of proteins. X-Ray crystal structures of enzyme-inhibitor complex indicate that the cysteine thiol reacts with the N-S bond of the thiadiazole moiety to form a disulfide bond resulting in the inactivation of the enzymes. This review addresses the medicinal chemistry and various properties of 1,2,4-thiadiazoles in their potential as new electrophilic “warheads” for targeting the cysteine residues of biomolecules (e.g, H+ / K+ ATPase), and cysteine-dependent enzymes (e.g., cathepsin B and transglutaminase).
Keywords: thiadiazole, proton pump, cathepsin b, factor xiiia, transglutaminase, cysteine thiol, inhibitors
Mini-Reviews in Medicinal Chemistry
Title: Medicinal Chemistry and Properties of 1,2,4-Thiadiazoles
Volume: 5 Issue: 4
Author(s): Tim Fat Tam, Regis Leung-Toung, Wanren Li, Michael Spino and Khashayar Karimian
Affiliation:
Keywords: thiadiazole, proton pump, cathepsin b, factor xiiia, transglutaminase, cysteine thiol, inhibitors
Abstract: 1,2,4-Thiadiazole is a distinctive class of small heterocyclic thiol trapping agents that serve as an interesting pharmacophore in the design of inhibitors targeting the cysteine residues of proteins. X-Ray crystal structures of enzyme-inhibitor complex indicate that the cysteine thiol reacts with the N-S bond of the thiadiazole moiety to form a disulfide bond resulting in the inactivation of the enzymes. This review addresses the medicinal chemistry and various properties of 1,2,4-thiadiazoles in their potential as new electrophilic “warheads” for targeting the cysteine residues of biomolecules (e.g, H+ / K+ ATPase), and cysteine-dependent enzymes (e.g., cathepsin B and transglutaminase).
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Cite this article as:
Tam Fat Tim, Leung-Toung Regis, Li Wanren, Spino Michael and Karimian Khashayar, Medicinal Chemistry and Properties of 1,2,4-Thiadiazoles, Mini-Reviews in Medicinal Chemistry 2005; 5 (4) . https://dx.doi.org/10.2174/1389557053544056
DOI https://dx.doi.org/10.2174/1389557053544056 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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