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Current Respiratory Medicine Reviews


ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Mitochondrial Therapy: New Strategy in Preventing Oxidant-Induced Lung Injury

Author(s): Yuchi Li, Yuko Arita and Jeffrey A. Kazzaz

Volume 1, Issue 2, 2005

Page: [197 - 202] Pages: 6

DOI: 10.2174/1573398054023082

Price: $65


Enhanced mitochondrial oxidative damage has been implicated in pathogenesis of various human diseases. This mini review will discuss the role of mitochondria in oxidative lung injury and the pathways induced by oxidant signaling. Recent studies suggest that mitochondrial targeting of antioxidants can reduce oxidant signaling and oxidant-stress while preserving mitochondrial structure and function. The impact on the treatment and prevention of acute lung injury will also be discussed.

Keywords: hyperoxia, ros, mitochondria, antioxidant enzyme, cell death, jnk pathways

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