Abstract
Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective antimetastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.
Keywords: heparinoid, heparin, polyanion, heparanase inhibitors, poly(acryl amino acid), fgf release, heparan sulfate, anticoagulant
Mini-Reviews in Medicinal Chemistry
Title: Structure and Biological Activity of Heparinoid
Volume: 5 Issue: 5
Author(s): Neeraj Kumar, A. Bentolila and A. J. Domb
Affiliation:
Keywords: heparinoid, heparin, polyanion, heparanase inhibitors, poly(acryl amino acid), fgf release, heparan sulfate, anticoagulant
Abstract: Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have been investigated with the objective of developing heparin-like molecules with reduced anti-coagulant activity and selective antimetastasis and anti-restenosis activity. This mini-review summarizes the synthesis and biological activity of the main synthetic heparinoids reported in the past three decades.
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Cite this article as:
Kumar Neeraj, Bentolila A. and Domb J. A., Structure and Biological Activity of Heparinoid, Mini-Reviews in Medicinal Chemistry 2005; 5 (5) . https://dx.doi.org/10.2174/1389557053765538
DOI https://dx.doi.org/10.2174/1389557053765538 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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