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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Recent Advances in Microwave-Assisted Synthesis of Heterocyclic Compounds

Author(s): Valentina Molteni and David A. Ellis

Volume 2 , Issue 3 , 2005

Page: [333 - 375] Pages: 43

DOI: 10.2174/1570179054368518

Price: $65


Heterocyclic scaffolds represent the central framework of many biologically active compounds. The goal of this review is to present advances in the field of microwave-assisted synthesis of heterocyclic compounds that have been described in the literature since 1994. In particular, it focuses on reactions in which a heteroatom is directly participating in the bond forming process that gives rise to a heterocyclic core. The review is divided into two sections, cycloaddition and cyclization reactions, which are further classified according to ring type. These reactions are discussed from a synthetic standpoint with emphasis on comparison between microwave and conventional techniques.

Keywords: microwave technology, acylation, deprotection, cycloaddition, polarization, single-mode reactors, isoxazolidines, indolizines, diels-alder reaction, thiiranes

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