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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Antiangiogenesis by Chemotherapeutic Agents

Author(s): Domenico Ribatti, Angelo Vacca, Francesca Merchionne and Marco Presta

Volume 5, Issue 3, 2005

Page: [313 - 317] Pages: 5

DOI: 10.2174/1389557053175353

Price: $65


Many tumors are not curable because current treatments primarily target the tumor cells. Intratumoral endothelial cells, on the other hand, proliferate rapidly and are sensitive to the cytotoxic effects of chemotherapeutic agents. This review summarizes the literature concerning the antiangiogenic effects of these agents when administered alone or in combination with other angiogenesis inhibitors.

Keywords: angiogenesis, antiangiogenesis, chemotherapeutic agents, endothelial cells, tumor progression

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