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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Brown Adipose Cell: A Unique Model for Understanding the Molecular Mechanism of Insulin Resistance

Author(s): Angela M. Valverde and Manuel Benito

Volume 5, Issue 3, 2005

Page: [269 - 278] Pages: 10

DOI: 10.2174/1389557053175380

Price: $65


Type 2 diabetes mellitus (NIDDM) is a complex metabolic disease that occurs when insulin secretion can no longer compensate insulin resistance in peripheral tissues. At the molecular level, insulin resistance correlates with impaired insulin signaling. This review provides new insights into the molecular mechanisms of insulin action and resistance in brown adipose tissue (BAT) and pinpoints the role of BAT in the control of glucose homeostasis.

Keywords: brown adipocytes, insulin signaling, insulin resistance, insulin receptor, insulin receptor substrates, adipocyte differentiation

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