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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Polyoxotungstates Reduce the β-Lactam Resistance of Methicillin-Resistant Staphylococcus aureus

Author(s): Yutaka Tajima

Volume 5, Issue 3, 2005

Page: [255 - 268] Pages: 14

DOI: 10.2174/1389557053175344

Price: $65

Abstract

Bacterial strains isolated from clinical specimens have become more and more resistant to many antimicrobials. This is because we have consumed large amounts of strong antimicrobials over long periods of time and thus bacterial cells are able to survive by altering the target(s) of antimicrobial agents. A good example of this phenomenon is methicillin-resistant Staphylococcus aureus (MRSA). One of the cell wallsynthesizing enzymes (known as PBP2;) of this pathogen has low affinity to βlactams, and therefore the bacterial cells continue to grow even under high concentrations of the agents. However, this drug resistance does not seem to be total. They seem to have some weak spots and several substances are known to sensitize strains of MRSA to βlactams. This review discusses the ability of polyoxotungstates (POTs) to sensitize MRSA to βlactams by reducing the expression of PBP2;. It is also possible that the sensitization is a type of stress response of MRSA to POTs. This idea may provide a hint for the development of a new antimicrobial agent.

Keywords: methicillin-resistant staphylococcus aureus, polyoxotungstate, lactam antibiotics, penicillin-binding protein


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