Abstract
The trifluoro analogue 1 of Casodex® was synthesized in racemic form, according to a strategy based on the use of trifluoropyruvate as a key starting material. This compound showed significant in vitro antiproliferative activity on the human prostate cancer cell line LNCaP.
Keywords: prostate cancer, anti-androgen, trifluoro-casodex analogue, nucleophilic reagents, chromatography
Call for Papers in Thematic Issues
Carbohydrates: Synthesis, properties and applications
This special issue on carbohydrates will the first of a series focused on the biomolecules, the following ones being amino acids / peptides, nucleosides / nucleotides, lipids. All the issues of the series will contain exclusively full-length reviews and mini-reviews on the given topic written by specialists working in technologically ...read more
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