Abstract
An innovative type of multifunctional helicoid artificial carriers, formed by the repetitive Lys-Aib-Gly (SOCn- I) or by the Aib-Lys-Aib-Gly (SOC n-II), with structural rigidity and regularity were successfully applied in our laboratory for anchoring antigenic/immunogenic peptides. The carriers, designed to display a predetermined 3D structure, adopt the 3 10 helical conformation, while the attached peptides preserve their original “active” conformation. The constructed conjugates were used as substrates in solid phase immunoassays, as well as for generating potent and specific immune responses.
Keywords: peptide technology, bovine serum albumin (bsa), protein carrier, (multiple antigenic peptides, sequential oligopeptide carriers, immunogenic proteins, orthogonal protection strategy, noe connectivities
Protein & Peptide Letters
Title: Innovative, Multifunctional Sequential Oligopeptide Carriers Socn-I and SOCn-II: Functions-Technology-Perspectives
Volume: 12 Issue: 6
Author(s): Charalampos Alexopoulos, Dimitrios Krikorian, Eugenia Panou-Pomonis, Maria Sakarellos-Daitsiotis and Constantinos Sakarellos
Affiliation:
Keywords: peptide technology, bovine serum albumin (bsa), protein carrier, (multiple antigenic peptides, sequential oligopeptide carriers, immunogenic proteins, orthogonal protection strategy, noe connectivities
Abstract: An innovative type of multifunctional helicoid artificial carriers, formed by the repetitive Lys-Aib-Gly (SOCn- I) or by the Aib-Lys-Aib-Gly (SOC n-II), with structural rigidity and regularity were successfully applied in our laboratory for anchoring antigenic/immunogenic peptides. The carriers, designed to display a predetermined 3D structure, adopt the 3 10 helical conformation, while the attached peptides preserve their original “active” conformation. The constructed conjugates were used as substrates in solid phase immunoassays, as well as for generating potent and specific immune responses.
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Cite this article as:
Alexopoulos Charalampos, Krikorian Dimitrios, Panou-Pomonis Eugenia, Sakarellos-Daitsiotis Maria and Sakarellos Constantinos, Innovative, Multifunctional Sequential Oligopeptide Carriers Socn-I and SOCn-II: Functions-Technology-Perspectives, Protein & Peptide Letters 2005; 12 (6) . https://dx.doi.org/10.2174/0929866054395914
DOI https://dx.doi.org/10.2174/0929866054395914 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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