Abstract
Most spider antimicrobial peptides share a common mechanism of membrane permeabilisation and the innate immune systems of the pathogen. In this review, we present recent accounts of the application at the preclinical level that should be tried and the range of bioactivities and their particular structure can be harnessed for molecular engineering applications and in drug design. Structural analyses such as amino acid sequence and circular dichroism are described. Conductance measurements and pharmacological studies of the action on the inner or outer membranes of anti-microbe will reveal more about the mode of action of the antimicrobial peptides of spider.
Keywords: venoms, neurotoxins, antimicrobial peptides, lycosa singoriensis, lycotoxin, tachystatin a, oxyopinin, gomesin
Call for Papers in Thematic Issues
Therapeutic Proteins and Peptides of Plant Origin
Plants are still the major repository of biologically active substances. In the last two decades, however, natural peptides and proteins of plant origin have gained increasing attention due to their pharmacological activities over a variety of human illnesses, including those mediated by infections and parasitosis and those involving different cellular ...read more
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