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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Synthesis of Proteins by Native Chemical Ligation Using Fmoc-Based Chemistry

Author(s): Julio A. Camarero and Alexander R. Mitchell

Volume 12, Issue 8, 2005

Page: [723 - 728] Pages: 6

DOI: 10.2174/0929866054864166

Price: $65


C-terminal peptide α-thioesters are valuable intermediates in the synthesis/semisynthesis of proteins by native chemical ligation. They are prepared either by solid-phase peptide synthesis (SPPS) or biosynthetically by protein splicing techniques. The present paper reviews the different methods available for the chemical synthesis of peptide α-thioesters using Fmoc-based SPPS.

Keywords: chemical protein synthesis, native chemical ligation, peptide thioester, hydrazine linker, protein engineering, fmoc-chemistry

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