Abstract
The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.
Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone
Mini-Reviews in Medicinal Chemistry
Title: Non-Steroidal Progesterone Receptor Specific Ligands
Volume: 5 Issue: 8
Author(s): G. F. Allan and Z. Sui
Affiliation:
Keywords: steroid receptors, abortion, knockout mice, pr-b isoform, breast cancer, progestin antagonists, carbamate, tetrahydrobenzindolone
Abstract: The nuclear receptor for progesterone is a target for contraception and for several therapeutic indications. Progestin agonists and antagonists in clinical use mimic the steroidal backbone of the cognate ligand, progesterone. Thus, they have significant cross-reactivity with other steroid receptors. Recently, nonsteroidal progesterone receptor ligands have begun to appear in the literature. This review will describe the current status of research into these promising new chemical entities.
Export Options
About this article
Cite this article as:
Allan F. G. and Sui Z., Non-Steroidal Progesterone Receptor Specific Ligands, Mini-Reviews in Medicinal Chemistry 2005; 5 (8) . https://dx.doi.org/10.2174/1389557054553794
DOI https://dx.doi.org/10.2174/1389557054553794 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Complex 3D Models to Study Drug Targeting of Invadopodia
Clinical Cancer Drugs Synergistic Interactions between GW8510 and Gemcitabine in an In Vitro Model of Pancreatic Cancer
Anti-Cancer Agents in Medicinal Chemistry Targeting Cyclooxygenase-2 in Hematological Malignancies: Rationale and Promise
Current Pharmaceutical Design New Molecular Targets of Anticancer Therapy – Current Status and Perspectives
Current Medicinal Chemistry Behavior of EDTMP (Ethylene-diaminetetramethylene-phosphonate)- Nanoparticles in Blood: Considerations on the Site of Injection
Current Nanoscience Type 2 Diabetes and Obesity Metabolic Interactions: Common Factors for Breast Cancer Risk and Novel Approaches to Prevention and Therapy
Current Diabetes Reviews Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues
Current Drug Metabolism Recent Advances in Liposomal Drug Delivery: A Review
Pharmaceutical Nanotechnology Targeting Tumor Proteasome with Traditional Chinese Medicine
Current Drug Discovery Technologies The Effects of Drug Metabolizing Enzyme Inhibitors on Hepatic Efflux and Uptake Transporters
Drug Metabolism Letters Recent Progress in the Development of Anticancer Agents
Current Medicinal Chemistry - Anti-Cancer Agents Protective Effects of Curcumin Against Nephrotoxic Agents
Cardiovascular & Hematological Disorders-Drug Targets Provoking Neuroprotection by Peroxynitrite
Current Pharmaceutical Design A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity
Current Drug Targets Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement
Current Pharmaceutical Design Targeting MDM4 as a Novel Therapeutic Approach for Hematologic Malignancies
Current Cancer Drug Targets PTEN, Insulin Resistance and Cancer
Current Pharmaceutical Design Editorial on the Occasion of the 20th Anniversary of Endocrine Metabolic Immune Disorders-Drug Targets Journal with a Kaleidoscopic Vision of Selected Publications
Endocrine, Metabolic & Immune Disorders - Drug Targets Bowman-Birk Inhibitors from Legumes and Human Gastrointestinal Health: Current Status and Perspectives
Current Protein & Peptide Science Deoxyribozymes as Inhibitors of Vascular Smooth Muscle Cell Growth
Current Pharmaceutical Biotechnology