A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

Title: A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

Volume: 2 Issue: 2

Author(s): John M. Ringman, Sally A. Frautschy, Gregory M. Cole, Donna L. Masterman and Jeffrey L. Cummings

Affiliation:

Keywords: curcuma longa, liver disease, anti-oxidant, cytokines, inflammation, (nsaid), cholesterol, fibrils, pharmacokinetic, microglia

Abstract: There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimers disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small shortterm studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.

Cite this article as:

Ringman M. John, Frautschy A. Sally, Cole M. Gregory, Masterman L. Donna and Cummings L. Jeffrey, A Potential Role of the Curry Spice Curcumin in Alzheimers Disease, Current Alzheimer Research 2005; 2(2) . https://dx.doi.org/10.2174/1567205053585882