Abstract
Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. The chemokine receptor CCR1 appears to be involved in a variety of proinflammatory and autoimmune diseases and this makes it a very attractive therapeutic target. This review discusses the identification, chemistry, biology and therapeutic potential of BX 471 a potent CCR1 antagonist that is currently in the clinic for a variety of indications.
Keywords: chemokine receptors, rantes, multiple sclerosis, rheumatoid arthritis, organ transplant rejection, atherosclerosis, psoriasis
Mini-Reviews in Medicinal Chemistry
Title: BX471: A CCR1 Antagonist with Anti-Inflammatory Activity in Man
Volume: 5 Issue: 9
Author(s): Richard Horuk
Affiliation:
Keywords: chemokine receptors, rantes, multiple sclerosis, rheumatoid arthritis, organ transplant rejection, atherosclerosis, psoriasis
Abstract: Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. The chemokine receptor CCR1 appears to be involved in a variety of proinflammatory and autoimmune diseases and this makes it a very attractive therapeutic target. This review discusses the identification, chemistry, biology and therapeutic potential of BX 471 a potent CCR1 antagonist that is currently in the clinic for a variety of indications.
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Cite this article as:
Horuk Richard, BX471: A CCR1 Antagonist with Anti-Inflammatory Activity in Man, Mini-Reviews in Medicinal Chemistry 2005; 5 (9) . https://dx.doi.org/10.2174/1389557054867057
DOI https://dx.doi.org/10.2174/1389557054867057 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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