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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Lactones: Generic Inhibitors of Enzymes?

Author(s): Monika I. Konaklieva and Balbina J. Plotkin

Volume 5, Issue 1, 2005

Page: [73 - 95] Pages: 23

DOI: 10.2174/1389557053402828

Price: $65

Abstract

The ability to affect eukaryotic and prokaryotic cellular growth, signaling and differentiation is a continuing focus in the pharmaceutical industry. The fundamental ability to affect these cellular processes is inherent in lactones. Lactones, which are ubiquitous in nature, reflect a broad phylogenetic diversity indicative of their ability to act as simple alkylating compounds, with their in situ activities falling into one of two categories, i.e., protect or conquer. Medically, their utility as pharmaceutical agents range from that of antimicrobial to anti-neoplastic agent depending on the functional groups attached.

Keywords: lactones, dna polymerases, human immunodeficiency virus type 1 (hiv-1) reverse transcriptase, cytokines

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