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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Recent Progress in Structure Activity Relationship and Mechanistic Studies of Taxol Analogues

Author(s): W.- S. Fang and X.- T. Liang

Volume 5, Issue 1, 2005

Page: [1 - 12] Pages: 12

DOI: 10.2174/1389557053402837

Price: $65


Structure activity relationship (SAR) and mechanism of paclitaxel and its analogues in recent years are discussed in the following areas: SAR of paclitaxel analogues toward “normal” and multi-drug resistance tumors; paclitaxel prodrugs with improved water solubitily and specificity; mechanism of paclitaxel related to tubulin binding and quest for its pharmacophore.

Keywords: anticancer drugs, paclitaxel, structure-activity relationship (sar), multi-drug resistance (mdr), prodrugs, microtubule, pharmacophore

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