Abstract
Olefin metathesis has rapidly established itself as an essential tool in the synthetic chemists armoury. The ease of operation and functional group tolerance that is obtained with the modern generation of catalysts makes the use of metathesis an extremely attractive option when preparing medicinally interesting molecules. This article will outline some of the ways in which chemists from both industry and academia have been utilising and developing metathesis in the search for novel biological probes and drug leads.
Keywords: peptidases, structure activity relationship, Diels-Alder reaction, photodynamic therapy (PDT), Chlorotritylpolystyrene, Valienamine, N-heterocyclic natural products
Current Topics in Medicinal Chemistry
Title: Ring Closing Metathesis in the Synthesis of Biologically Interesting Peptidomimetics, Sugars and Alkaloids
Volume: 5 Issue: 15
Author(s): William H.C. Martin and Siegfried Blechert
Affiliation:
Keywords: peptidases, structure activity relationship, Diels-Alder reaction, photodynamic therapy (PDT), Chlorotritylpolystyrene, Valienamine, N-heterocyclic natural products
Abstract: Olefin metathesis has rapidly established itself as an essential tool in the synthetic chemists armoury. The ease of operation and functional group tolerance that is obtained with the modern generation of catalysts makes the use of metathesis an extremely attractive option when preparing medicinally interesting molecules. This article will outline some of the ways in which chemists from both industry and academia have been utilising and developing metathesis in the search for novel biological probes and drug leads.
Export Options
About this article
Cite this article as:
Martin H.C. William and Blechert Siegfried, Ring Closing Metathesis in the Synthesis of Biologically Interesting Peptidomimetics, Sugars and Alkaloids, Current Topics in Medicinal Chemistry 2005; 5 (15) . https://dx.doi.org/10.2174/156802605775009757
DOI https://dx.doi.org/10.2174/156802605775009757 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
An Efficient Gram Scale Synthesis of Aryl Iodides from Aryl Diazofluoroborates in Water under Mild Conditions
Letters in Organic Chemistry Recent Advances and Patents on Solid Lipid Nanoparticles
Recent Patents on Drug Delivery & Formulation Cytokine/Antibody Complexes: An Emerging Class of Immunostimulants
Current Pharmaceutical Design Four Types of Novel Potential Malate Synthase Inhibitors from Virtual Screening
Current Enzyme Inhibition Tetraspanins - Gateways for Infection
Infectious Disorders - Drug Targets In Silico Discovery and Virtual Screening of Multi-Target Inhibitors for Proteins in Mycobacterium tuberculosis
Combinatorial Chemistry & High Throughput Screening Drugs Targeting Parasite Lysosomes
Current Pharmaceutical Design Fight Against H1N1 Influenza A Virus: Recent Insights Towards the Development of Druggable Compounds
Current Medicinal Chemistry Preface
Current Drug Targets - Infectious Disorders Significance of P2X7 Receptor Variants to Human Health and Disease
Recent Patents on DNA & Gene Sequences The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal Complexes
Mini-Reviews in Medicinal Chemistry Is There an Increased Risk of Lymphoma and Malignancies Under Anti- TNF Therapy in IBD?
Current Drug Targets Recent Development and Future Perspective of Antitubercular Therapy
Anti-Infective Agents in Medicinal Chemistry Management of Certain Respiratory Disorders through Ayurveda: A Systematic Review of Clinical Studies Published in Ayurveda Journal
Current Traditional Medicine Lactoferricin Derived From Milk Protein Lactoferrin
Current Pharmaceutical Design Bacterial β-ketoacyl-Acyl Carrier Protein Synthases as Targets for Antibacterial Agents
Current Protein & Peptide Science Phospho-MurNAc-Pentapeptide Translocase (MraY) as a Target for Antibacterial Agents and Antibacterial Proteins
Infectious Disorders - Drug Targets Beneficial Effects of Liposomal Formulations of Lichen Substances: A Review
Current Drug Delivery Neurocysticercosis: The Enigmatic Disease
Central Nervous System Agents in Medicinal Chemistry Editorial (Hot Topic: Vitamin D Deficiency and Critical Illness)
Inflammation & Allergy - Drug Targets (Discontinued)