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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Practical Aspects of NMR-based Fragment Discovery

Author(s): Edward R. Zartler and Huaping Mo

Volume 7 , Issue 16 , 2007

Page: [1592 - 1599] Pages: 8

DOI: 10.2174/156802607782341055

Price: $65

Abstract

Fragment-based drug discovery (FBDD) needs a biophysical assay to complement, or even replace, biochemical screening. NMR is the best choice for this because NMR delivers many different types of data that impacts medicinal chemistry decisions. There are a multitude of different NMR methods which can be employed to these ends. The choice of which method to use will be different for every need. We discuss the different methods, the data they produce, and how they are best utilized in a FBDD setting.

Keywords: NMR, Fragment, Screening, protein-based, ligand-based


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