One-Pot Synthesis of 1,3-Thiazolidin-4-Ones Derivatives from 2-Amino-1,3,4-Thiadiazole

Title: One-Pot Synthesis of 1,3-Thiazolidin-4-Ones Derivatives from 2-Amino-1,3,4-Thiadiazole

Volume: 4 Issue: 7

Author(s): Wilson Cunico, Claudia R. B. Gomes, Maria de Lourdes G. Ferreira, Liliane R. Capri, Margareth R. L. Santos, Paula M. Sa, Nubia Boechat, Monica M. Bastos, Lindalva C. Maciel and Lucia M. U. Mayer

Affiliation:

Keywords: 4-thiazolidinone, heterocycles, cyclocondensation

Abstract: Several 1,3-thiazolidin-4-ones were synthesized by cyclocondensation reaction of 2-amino-1,3,4-thiadiazole, mercaptoacetic acid and various arenealdehydes in moderate to good yields. These compounds were characterized by 1H, 13C and 19F NMR. The antimalarial activity of thiazolidinones was evaluated in vitro against Plasmodium falciparum clone but none of them showed activity at maximum concentration (50μg/ml) used.

Cite this article as:

Cunico Wilson, Gomes R. B. Claudia, Ferreira G. Maria de Lourdes, Capri R. Liliane, Santos R. L. Margareth, Sa M. Paula, Boechat Nubia, Bastos M. Monica, Maciel C. Lindalva and Mayer M. U. Lucia, One-Pot Synthesis of 1,3-Thiazolidin-4-Ones Derivatives from 2-Amino-1,3,4-Thiadiazole, Letters in Organic Chemistry 2007; 4 (7) . https://dx.doi.org/10.2174/157017807782006245