Antibacterial Activity of 3-Substituted Pyrrole-2,5-diones Against Pseudomonas Aeruginosa

Title: Antibacterial Activity of 3-Substituted Pyrrole-2,5-diones Against Pseudomonas Aeruginosa

Volume: 4 Issue: 7

Author(s): Eric Lattmann, Simon Dunn, Suwanna Niamsanit, Jintana Sattayasai and Nison Sattayasai

Affiliation:

Keywords: Halogenated pyrrole, Antibacterial, Pseudomonas aeruginosa, OprF-related protein

Abstract: 3-Substituted pyrrole-2,5-diones were synthesised from mucohalogen acids and the antibacterial activity was subsequently determined in biological assays. The minimum inhibitory concentration and the minimum bactericidal concentration of 2a were determined for a wide range of microorganisms in the low micromolar range. Protein identification using SDS-PAGE and LC/MS/MS demonstrated a partly degradation of OprF-related proteins giving an insight into the underlying mechanism of these novel antibacterial agents.

Cite this article as:

Lattmann Eric, Dunn Simon, Niamsanit Suwanna, Sattayasai Jintana and Sattayasai Nison, Antibacterial Activity of 3-Substituted Pyrrole-2,5-diones Against Pseudomonas Aeruginosa, Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788570