Generic placeholder image

Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Effect of the Metal Center on the Antitumor Activity of the Analogous Dinuclear Spermine Chelates (PdCl2)2(Spermine) and (PtCl2)2(Spermine)

Author(s): Ana S. Soares, Sonia M. Fiuza, M. Joao Goncalves, Luis A.E. Batista de Carvalho, M. Paula M. Marques and Ana M. Urbano

Volume 4, Issue 7, 2007

Page: [460 - 463] Pages: 4

DOI: 10.2174/157018007781788516

Price: $65


The cytotoxic activity of (PdCl2)2(spermine) against a human cancer cell line (HSC-3) was evaluated. The results show an activity higher than that of the analogous Pt(II) chelate and, for 24 h incubations, identical to that of cisplatin. They also suggest a faster intracellular uptake and DNA binding relative to cisplatin.

Keywords: Multinuclear polyamine complexes, Pt(II), Pd(II), Spermine, Cytotoxic Activity, Anticancer potential

Next »

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy