Synthesis and Biological Activity of 3-(2, 8, 9-Trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic Acids

Title: Synthesis and Biological Activity of 3-(2, 8, 9-Trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic Acids

Volume: 3 Issue: 5

Author(s): Lianbao Ye and Wanjin Zhang

Affiliation:

Keywords: Germanium, cinnamic acid, hydroxyl-cinnamic acid germanium, synthesis, trichlorogermane, germatrane, u14 tumor-cell, antitumor activity, tumor inhibitory

Abstract: The new germanium compounds of cinnamic acid, RC6H4CHGe(OCH2CH2)3NCH2COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study anti-tumor activities. Compounds (I-IV) were prepared by the electrophilic addition reaction and nucleophilic substitution reaction. Biological investigation has demonstrated that all compounds (I-IV) are lower toxicity with strongly anti-tumor activity than positive control.

Cite this article as:

Ye Lianbao and Zhang Wanjin, Synthesis and Biological Activity of 3-(2, 8, 9-Trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic Acids, Medicinal Chemistry 2007; 3 (5) . https://dx.doi.org/10.2174/157340607781745465