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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Facile Biphasic Deprotection of Aldehyde Dimethylhydrazones with Aqueous Hydrochloric Acid

Author(s): Richard J. Petroski

Volume 4, Issue 6, 2007

Page: [452 - 455] Pages: 4

DOI: 10.2174/157017807781467551

Price: $65

Abstract

Deprotection of aldehyde dimethylhydrazones was accomplished by stirring a biphasic mixture of the aldehyde dimethylhydrazone, 1M hydrochloric acid, and petroleum ether at room temperature for three to seven hours. The method works with α,β-unsaturated- and diene-aldehyde dimethylhydrazones, which are often difficult compounds to deprotect. Isolated yields ranged from 85% to 97%.

Keywords: Aldehyde dimethylhydrazone, deprotection, biphasic, hydrochloric acid

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