High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

O.      Azzolina; S.      Collina; D.      Rossi; A.      Carnevale Baraglia; S.      Alcaro; A.      Artese

Abstract

In the last five years we prepared and studied some dialkylaminoalkylnaphthalenes and cycloaminoalkylnaphthalenes with interesting opioid-like analgesic activity. In this paper we report on their lipophilicity evaluation combining computational and RP-HPLC experiments. A suitable computational method for the high-throughput log P screening was identified.

Keywords: Dialkylaminoalkylnaphthalenes, cycloaminoalkylnaphthalenes, opioid-like analgesics, log P, RP-HPLC, computational methods

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Letters in Drug Design & Discovery

Title: High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

Volume: 3 Issue: 6

Author(s): O. Azzolina, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro and A. Artese

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Keywords: Dialkylaminoalkylnaphthalenes, cycloaminoalkylnaphthalenes, opioid-like analgesics, log P, RP-HPLC, computational methods

Abstract: In the last five years we prepared and studied some dialkylaminoalkylnaphthalenes and cycloaminoalkylnaphthalenes with interesting opioid-like analgesic activity. In this paper we report on their lipophilicity evaluation combining computational and RP-HPLC experiments. A suitable computational method for the high-throughput log P screening was identified.

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Azzolina O., Collina S., Rossi D., Carnevale Baraglia A., Alcaro S. and Artese A., High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis, Letters in Drug Design & Discovery 2006; 3(6) . https://dx.doi.org/10.2174/157018006777805530