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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

High-Throughput Lipophilicity Screening of Opioid-Like Analgesics: Validation of Computational Methods by Means of RP-HPLC Analysis

Author(s): O. Azzolina, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro and A. Artese

Volume 3, Issue 6, 2006

Page: [413 - 418] Pages: 6

DOI: 10.2174/157018006777805530

Price: $65


In the last five years we prepared and studied some dialkylaminoalkylnaphthalenes and cycloaminoalkylnaphthalenes with interesting opioid-like analgesic activity. In this paper we report on their lipophilicity evaluation combining computational and RP-HPLC experiments. A suitable computational method for the high-throughput log P screening was identified.

Keywords: Dialkylaminoalkylnaphthalenes, cycloaminoalkylnaphthalenes, opioid-like analgesics, log P, RP-HPLC, computational methods

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