A Convenient Synthesis of Novel Substituted Isoxazolo[5,4-d]Pyrimidines

Title: A Convenient Synthesis of Novel Substituted Isoxazolo[5,4-d]Pyrimidines

Volume: 4 Issue: 4

Author(s): Sergey B. Aliabiev, Raisa V. Bykova, Dmitri V. Kravchenko and Alexandre V. Ivachtchenko

Affiliation:

Keywords: Cyclization, heterocycle, isoxazolo[5,4-d]pyrimidine, amines, carboxamides, library

Abstract: In this work, we present a convenient synthetic route to novel substituted derivatives of isoxazolo[5,4-d]pyrimidines. Starting from 5-amino-isoxazole-4-carboxamides, we have obtained a series of 3,6-substituted isoxazolo[5,4-d]pyrimidin-4(5H)-ones via intermolecular cyclization of initial heterocycles with ethyl triethoxyacetate or diethyl oxalate/succinate. We have also synthesized a number of 4-amino substituted isoxazolo[5,4-d]pyrimidines and 4-amino-isoxazolo[5,4-d]pyrimidine-6-carboxamides using a convenient and simple synthetic approach. We demonstrate the usefulness and versatility of the developed strategy, which can be easily adapted to high-throughput combinatorial format, for the synthesis of variously substituted compounds containing this core fragment.

Cite this article as:

Sergey B. Aliabiev , Raisa V. Bykova , Dmitri V. Kravchenko and Alexandre V. Ivachtchenko , A Convenient Synthesis of Novel Substituted Isoxazolo[5,4-d]Pyrimidines, Letters in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157017807781024183