Abstract
Currently, the generation of peptide ligand libraries where ligand position and identity are varied leading to the discovery of optimal peptide activity and stability is limited. Thus, in this work the synthesis of a p-Dde-Nα-Fmocphenylalanine residue is reported followed by its application in the microwave assisted synthesis of labeled HYNIC Phe8- oxitocine derivatives.
Keywords: Microwave, oxytocin, HYNIC, peptide, libraries, conjugate
Letters in Organic Chemistry
Title: From Head to Tail: Microwave-Assisted Synthesis of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives
Volume: 4 Issue: 4
Author(s): Alma D. Miranda-Olvera, Ignacio A. Rivero Espejel and Luis M. De Leon Rodriguez
Affiliation:
Keywords: Microwave, oxytocin, HYNIC, peptide, libraries, conjugate
Abstract: Currently, the generation of peptide ligand libraries where ligand position and identity are varied leading to the discovery of optimal peptide activity and stability is limited. Thus, in this work the synthesis of a p-Dde-Nα-Fmocphenylalanine residue is reported followed by its application in the microwave assisted synthesis of labeled HYNIC Phe8- oxitocine derivatives.
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Alma D. Miranda-Olvera , Ignacio A. Rivero Espejel and Luis M. De Leon Rodriguez , From Head to Tail: Microwave-Assisted Synthesis of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives, Letters in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157017807781024246
DOI https://dx.doi.org/10.2174/157017807781024246 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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