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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Mild and Efficient C-3 Allylic Alkylation of Indoles Catalyzed by FeCl3

Author(s): Zhe Liu, Li Liu, Zahid Shafiq, Dong Wang and Yong-Jun Chen

Volume 4, Issue 4, 2007

Page: [256 - 260] Pages: 5

DOI: 10.2174/157017807781024336

Price: $65

Abstract

A mild and efficient allylic alkylation of indole derivatives has been developed with high regioselectivity and excellent yields. In the presence of 1mol% FeCl3 catalyst, various indole derivatives could react with allylic acetates at room temperature to provide C-3 allylation products. A green synthesis of C-3 allylated indoles was developed employing FeCl3 as catalyst in water.

Keywords: Allylation, FeCl3, indole, Friedel-Crafts alkylation, allylic acetate


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