Characterization of Antibody-Binding Sites on Proteins: Development of a Knowledgebase and Its Applications in Improving Epitope Prediction

Title: Characterization of Antibody-Binding Sites on Proteins: Development of a Knowledgebase and Its Applications in Improving Epitope Prediction

Volume: 14 Issue: 6

Author(s): A.D. Ghate, B.U. Bhagwat, S.G. Bhosle, S.M. Gadepalli and U.D. Kulkarni-Kale

Affiliation:

Keywords: Immunoinformatics, Bioinformatics, conformational or discontinuous epitope, B-cell epitope prediction, antigenantibody interactions, derived database

Abstract: Immunoinformatics provides tools for reverse vaccinology and encompasses development of knowledge bases and algorithms for prediction of epitopes. AgAbDb, a database archiving molecular interactions of antigen-antibody cocrystal structures, has been developed (http://202.41.70.51:8080/agabdb2/). Analyses of antibody-binding sites on proteins helped to fine-tune the parameters for prediction of sequential and conformational B-cell epitopes.

Cite this article as:

A.D. Ghate , B.U. Bhagwat , S.G. Bhosle , S.M. Gadepalli and U.D. Kulkarni-Kale , Characterization of Antibody-Binding Sites on Proteins: Development of a Knowledgebase and Its Applications in Improving Epitope Prediction, Protein & Peptide Letters 2007; 14 (6) . https://dx.doi.org/10.2174/092986607780989921