Allosteric Enhancers for A1 Adenosine Receptor

Pier Giovanni Baraldi; Maria Antonietta Iaconinoto; Allan R. Moorman; Maria Dora Carrion; Carlota Lopez Cara; Delia Preti; Olga Cruz Lopez; Francesca Fruttarolo; Mojgan Aghazadeh Tabrizi; Romeo Romagnoli

Abstract

Allosteric enhancers at the adenosine A1 receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, allosteric modulators at the adenosine A1 receptor have therapeutic potential as analgesics and neuroprotective agents. In particular, the compounds with improved potency as enhancers and reduced antagonist properties are mentioned.

Keywords: A1-adenosine receptor, allosteric modulators, enhancer, cAMP content, neuroprotection