Generic placeholder image

Central Nervous System Agents in Medicinal Chemistry


ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

Regulators of the G1 Phase of the Cell Cycle and Neurogenesis

Author(s): Maryline Paris and Ourania M. Andrisani

Volume 7, Issue 2, 2007

Page: [115 - 128] Pages: 14

DOI: 10.2174/187152407780831675

Price: $65


During neurogenesis, precursor cells undergo a defined number of divisions and terminally differentiate as postmitotic neurons. In the adult mammal, under certain conditions, postmitotic neurons re-enter the cell cycle and divide. The accumulated evidence demonstrates that the precise control of cell-cycle progression is critical for both neuronal development and maintenance of the neuronal phenotype. Cyclin-dependent Kinase Inhibitors (CDKIs) play the key role in this neuronal differentiation process of coordinating cell cycle exit and differentiation. Importantly, deregulation of the cell cycle leads to a variety of human neuronal diseases. In this review we discuss how regulation of neuronal progenitor proliferation and neuronal differentiation are coupled processes, based on evidence derived from the study of multiple animal models (mouse, Drosophila and Xenopus). In addition, we discuss the involvement of CDKIs in human neuronal diseases including cancers of neuronal systems, Alzheimer ’ s disease, and psychological disorders, and their potential as pharmacological targets.

Keywords: Cell cycle, G1/S phase, cyclin dependent kinase inhibitor, neuronal differentiation

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy