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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3-Azido-3-Deoxythymidine

Author(s): Peiyuan Jin, Sanhao Ji, Yong Ju and Yufen Zhao

Volume 4 , Issue 3 , 2007

Page: [189 - 192] Pages: 4

DOI: 10.2174/157017807780737336

Price: $65


Some steroidal phosphorothioate, phosphoroselenoate, and phosphate derivatives conjugated with 3-Azido-3-deoxythymidine (AZT) have been synthesized in good yields and their structures were confirmed on the basis of spectral methods. The result has shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.

Keywords: Steroidal conjugate, AZT, phosphate, cytotoxic activity

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