Abstract
The Transforming Growth Factor-β (TGFβ) superfamily of cytokines regulates a myriad of cellular processes including proliferation, differentiation and tumorigenesis. Signaling by these growth regulatory molecules is propagated by ligand-induced heterooligomerization of distinct type II and type I serine/threonine kinase receptors, which result in activation of receptor-activated Smad proteins as well as Smad-independent pathways. Disruption of TGFβ induced signaling can contribute to development and progression of human breast cancer. The role of Smad-signaling in mammary gland development and tumorigenesis will be the focus of this review.
Keywords: TGFβ, activin, inhibin, BMP, MIS, nodal, cripto-1, smads, breast cancer
Call for Papers in Thematic Issues
Metabolism in Inflammation-Induced Cancer
We will talk about the primary mechanisms and principles of inflammation-induced cancer based on the most recent research findings and our understanding of the tumor development process, with an emphasis on the crosstalk between metabolism and inflammation-induced cancer. The regulatory mechanisms of T cell subpopulation differentiation, the regulatory function of ...read more
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