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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains

Author(s): Jerzy Gubernator, Zuzanna Drulis-Kawa, Agata Dorotkiewicz-Jach, Wlodzimierz Doroszkiewicz and Arkadiusz Kozubek

Volume 4, Issue 4, 2007

Page: [297 - 304] Pages: 8

DOI: 10.2174/157018007784620040

Price: $65


The antimicrobial activity of two cationic liposomes containing three antibiotics were tested in vitro. Ciprofloxacin loaded in liposomes exhibited a 2-4 times higher antimicrobial activity compared with the free drug. The bacterial sensitivity to liposomal meropenem were similar as to free antibiotic. The least effective were the liposomes containing gentamicin.

Keywords: Liposomes, Meropenem, Gentamicin, Ciprofloxacin, Bacteria

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