Abstract
The semi-thiosemicarbazone and N4-substituted thiosemicarbazone derivatives and their metal complexes of the active principle of Henna were structurally characterized along with single crystal X-ray studies. The compounds were evaluated for their antiproliferative activity against human leukemia KBM-5 cells, where [Cu(3)] was the most active compound with IC50 of 0.3 μM attributed to down regulation of NF-κB activation.
Keywords: Human myeloid leukemia, Copper complexes, Naphthoquinones, Sulforaphanes, NF-κB inhibition, Henna derivatives
Letters in Drug Design & Discovery
Title: Copper Complexes of Henna-Sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB
Volume: 4 Issue: 4
Author(s): K. Shirisha, J. Patole, S. Padhye, E. Sinn, S. Shishodia and B. B. Aggarwal
Affiliation:
Keywords: Human myeloid leukemia, Copper complexes, Naphthoquinones, Sulforaphanes, NF-κB inhibition, Henna derivatives
Abstract: The semi-thiosemicarbazone and N4-substituted thiosemicarbazone derivatives and their metal complexes of the active principle of Henna were structurally characterized along with single crystal X-ray studies. The compounds were evaluated for their antiproliferative activity against human leukemia KBM-5 cells, where [Cu(3)] was the most active compound with IC50 of 0.3 μM attributed to down regulation of NF-κB activation.
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Cite this article as:
Shirisha K., Patole J., Padhye S., Sinn E., Shishodia S. and Aggarwal B. B., Copper Complexes of Henna-Sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB, Letters in Drug Design & Discovery 2007; 4 (4) . https://dx.doi.org/10.2174/157018007784620059
DOI https://dx.doi.org/10.2174/157018007784620059 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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