Abstract
Renal tubular acidosis (RTA), a clinical syndrome with hyperchloremic metabolic acidosis with normal anion gap, is an uncommon and sometimes overlooked condition. It may have multiple causes, some sporadic, some genetically transmitted; some are isolated or may be associated with other renal or systemic pathologies or diseases. All these factors add to the complexity of recognition and management of this extended range of conditions. We hereby describe several children with different types of RTA, illustrating the different mode of presentations and some of the etiologies. Pathophysiology is reviewed, as well as the practical approach to the diagnosis and management. In addition, recent genetically identified conditions are reviewed, with emphasis on increasingly recognized association with other systems involvement.
Keywords: Acidosis, renal tubular, complications, diagnosis, etiology
Current Pediatric Reviews
Title: Renal Tubular Acidosis
Volume: 3 Issue: 2
Author(s): Iradj Amirlak, Hassib Narchi and Lihadh Al-Gazali
Affiliation:
Keywords: Acidosis, renal tubular, complications, diagnosis, etiology
Abstract: Renal tubular acidosis (RTA), a clinical syndrome with hyperchloremic metabolic acidosis with normal anion gap, is an uncommon and sometimes overlooked condition. It may have multiple causes, some sporadic, some genetically transmitted; some are isolated or may be associated with other renal or systemic pathologies or diseases. All these factors add to the complexity of recognition and management of this extended range of conditions. We hereby describe several children with different types of RTA, illustrating the different mode of presentations and some of the etiologies. Pathophysiology is reviewed, as well as the practical approach to the diagnosis and management. In addition, recent genetically identified conditions are reviewed, with emphasis on increasingly recognized association with other systems involvement.
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Cite this article as:
Amirlak Iradj, Narchi Hassib and Al-Gazali Lihadh, Renal Tubular Acidosis, Current Pediatric Reviews 2007; 3 (2) . https://dx.doi.org/10.2174/157339607780599038
DOI https://dx.doi.org/10.2174/157339607780599038 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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In early life, organs and hormonal axes are especially susceptible to changes that can affect the intestinal mucosa, immune system, and long-term health. Critical factors in the developmental process, including maternal diet, type of delivery, breastfeeding, and the nutritional status of mothers and children, have gained prominence. Evidence suggests that ...read more

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