Abstract
Indoles are abundant in nature, and exhibit important biological properties such as anti-inflammatory, antihypertensive, dopaminergic, antineoplastic, anticonvulsant, analgesic, sedative, muscle relaxant, and antimicrobial activities. Synthesis, and functionalization of pharmacologically active indoles continue to receive considerable attention in the field of synthetic organic chemistry. Recent advances toward synthesis of natural, and unnatural indoles have been accelerated by transition metal catalysts, and in the context rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations with quite often-unique selectivity. This review describes the formation of indoles via rhodium catalyzed C-H, and X-H insertion (X = N, O, and S), cycloaddition, hydroformylation, bimetallic, and asymmetric hydrogenation reactions. Use of solid phase chemistry in rhodium catalyzed indole synthesis has also been discussed in the article.
Keywords: Indoles, Rhodium(II)-catalyst, Insertion, Cycloaddition, Hydrogination, Solid-phase
Current Organic Synthesis
Title: Synthesis and Functionalization of Indoles through Rhodium-Catalyzed Reactions
Volume: 4 Issue: 2
Author(s): Shivaputra Patil and Renukadevi Patil
Affiliation:
Keywords: Indoles, Rhodium(II)-catalyst, Insertion, Cycloaddition, Hydrogination, Solid-phase
Abstract: Indoles are abundant in nature, and exhibit important biological properties such as anti-inflammatory, antihypertensive, dopaminergic, antineoplastic, anticonvulsant, analgesic, sedative, muscle relaxant, and antimicrobial activities. Synthesis, and functionalization of pharmacologically active indoles continue to receive considerable attention in the field of synthetic organic chemistry. Recent advances toward synthesis of natural, and unnatural indoles have been accelerated by transition metal catalysts, and in the context rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations with quite often-unique selectivity. This review describes the formation of indoles via rhodium catalyzed C-H, and X-H insertion (X = N, O, and S), cycloaddition, hydroformylation, bimetallic, and asymmetric hydrogenation reactions. Use of solid phase chemistry in rhodium catalyzed indole synthesis has also been discussed in the article.
Export Options
About this article
Cite this article as:
Patil Shivaputra and Patil Renukadevi, Synthesis and Functionalization of Indoles through Rhodium-Catalyzed Reactions, Current Organic Synthesis 2007; 4 (2) . https://dx.doi.org/10.2174/157017907780598862
DOI https://dx.doi.org/10.2174/157017907780598862 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Effect of Aspirin on the Prevention of Pro-thrombotic States in Hospitalized
COVID-19 Patients: Systematic Review
Cardiovascular & Hematological Agents in Medicinal Chemistry Food Allergy
Current Pharmaceutical Design Design and Development of Smart and Safe Helmet for Inhibiting COVID-19 Virus Infection: A Simple Idea for Solving the Big Crisis
Coronaviruses Cellular and Molecular Aspects of Managing Familial Hypercholesterolemia: Recent and Emerging Therapeutic Approaches
Endocrine, Metabolic & Immune Disorders - Drug Targets Synthesis and Evaluation of Chalcone and its Derivatives as Potential Anticholinergic Agents
Letters in Drug Design & Discovery Estimating COVID-19 Cases Using Machine Learning Regression Algorithms
Recent Advances in Electrical & Electronic Engineering The Role of Antihistamine Drugs in Allergic Disorders
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Imaging Studies in Hypercalcemia
Current Medicinal Chemistry Antimicrobial Activity and SAR Study of Some Novel Thiosemicarbazide Derivatives Bearing Piperidine Moiety
Medicinal Chemistry Quantum Mechanical Methods for Drug Design
Current Topics in Medicinal Chemistry Meet Our Editorial Board Member
Protein & Peptide Letters Small Molecule Approaches Toward the Non-Microbicidal Modulation of Bacterial Biofilm Growth and Maintenance
Anti-Infective Agents in Medicinal Chemistry Ancient Wheat as Promising Nutraceuticals for the Prevention of Chronic and Degenerative Diseases
Current Medicinal Chemistry The Relationship Between 24-Hour Indicators and Mortality in Patients with Exertional Heat Stroke
Endocrine, Metabolic & Immune Disorders - Drug Targets Substructural Analysis in Drug Discovery
Current Computer-Aided Drug Design Pharmacophore Based 3D-QSAR Modeling and Molecular Docking of Leucettines as Potent Dyrk1A Inhibitors
Letters in Drug Design & Discovery N-Methylated α-Amino Acids And Peptides: Synthesis And Biological Activity
Mini-Reviews in Medicinal Chemistry BDZs, Designer BDZs and Z-drugs: Pharmacology and Misuse Insights
Current Pharmaceutical Design A Comparative Insight on the Newly Emerging Rifamycins: Rifametane, Rifalazil, TNP-2092 and TNP-2198
Current Medicinal Chemistry The Role of Inflammatory and Cytokine Biomarkers in the Pathogenesis of Frailty Syndrome
Endocrine, Metabolic & Immune Disorders - Drug Targets