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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Characterization of a Novel ADPase in Bothrops jararaca Snake Venom Involved in Nucleotide Hydrolysis

Author(s): Andre Teixeira-Ferreira and Elias Walter Alves

Volume 14, Issue 4, 2007

Page: [395 - 402] Pages: 8

DOI: 10.2174/092986607780363998

Price: $65

Abstract

Snake venoms hydrolyze several phosphorylated substrates. However, not is clearly understood which enzyme( s) is (are) involved in these process. Here, we propose the existence of an independent ADPase activity. In addition, we studied the reactions mechanism of nucleotide hydrolysis. This system resembles membrane ecto-nucleotidases and acts with a multi enzymatic complex transforming ATP in adenosine without the accumulation of intermediates.

Keywords: Bothrops jararaca, ATP-pyrophosphatase, ATPase, ADPase, Phosphodiesterase, 5'-nucleotidase


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