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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Fondaparinux: Pharmacology and Clinical Experience in Cardiovascular Medicine

Author(s): V. Toschi and M. Lettino

Volume 7, Issue 4, 2007

Page: [383 - 387] Pages: 5

DOI: 10.2174/138955707780363819

Price: $65

Abstract

Fondaparinux is a synthetic, five-saccharide chain, AT-dependent, anti-FXa agent. Studies showed that fondaparinux acts in prevention and treatment of venous thromboembolism and in ischemic heart disease, without significant bleeding risk. The drug inhibits thrombin generation, has long half-life and can be administered once-daily without laboratory monitoring. It may be used in HIT treatment.

Keywords: Antithrombotic, factor Xa inhibitor, heparin, low molecular weight heparin, fondaparinux


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