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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Raxofelast, (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic Acid: A New Antioxidant to Modulate the Inflammatory Response During Ischemia-Reperfusion Injury and Impaired Wound Healing

Author(s): A. Bitto, L. Minutoli, F. Squadrito, F. Polito and D. Altavilla

Volume 7, Issue 3, 2007

Page: [339 - 343] Pages: 5

DOI: 10.2174/138955707780059835

Price: $65


Raxofelast, also named IRFI 016 or (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic acid, belongs to a family of novel molecules designed with the aim to maximize antioxidant potency of phenols related to Vitamin E ( α-tocopherol). This review will focus on the antioxidant and radical scavenging activity of this new promising compound.

Keywords: Raxofelast, inflammation, ischemia/reperfusion injury, wound healing, diabetes, safety

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