Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D

Title: Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D

Volume: 4 Issue: 3

Author(s): Manu Sharma, Pritam Dev Sharma, Mohinder Pal Bansal and Jaswant Singh

Affiliation:

Keywords: Lantadene D, Cytotoxicity, Antitumor, 12-O- Tetradecanoylphorbol-13 acetate (TPA), 7, 12-Dimethylbenz [a] anthracene (DMBA)

Abstract: Lantadene D was semi-synthetically prepared by functionalizing 22β-hydroxyoleanonic acid and screened for cytotoxicity against four human cancer cell lines (HL-60, HeLa, Colon 502713 and Lung A-549). It was further evaluated for its inhibitory profile against two-stage carcinogenesis in Swiss albino mice.

Cite this article as:

Sharma Manu, Dev Sharma Pritam, Pal Bansal Mohinder and Singh Jaswant, Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077471