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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D

Author(s): Manu Sharma, Pritam Dev Sharma, Mohinder Pal Bansal and Jaswant Singh

Volume 4, Issue 3, 2007

Page: [201 - 206] Pages: 6

DOI: 10.2174/157018007780077471

Price: $65


Lantadene D was semi-synthetically prepared by functionalizing 22β-hydroxyoleanonic acid and screened for cytotoxicity against four human cancer cell lines (HL-60, HeLa, Colon 502713 and Lung A-549). It was further evaluated for its inhibitory profile against two-stage carcinogenesis in Swiss albino mice.

Keywords: Lantadene D, Cytotoxicity, Antitumor, 12-O- Tetradecanoylphorbol-13 acetate (TPA), 7, 12-Dimethylbenz [a] anthracene (DMBA)

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