Abstract
The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.
Keywords: Pharmacones clathration, Nifedipine, Glycyrrhizic acid, Calcium channels
Letters in Drug Design & Discovery
Title: Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides
Volume: 4 Issue: 3
Author(s): T. G. Tolstikova, A. O. Bryzgalov, I. V. Sorokina, M. V. Hvostov, A. S. Ratushnyak, T. A. Zapara and O. G. Simonova
Affiliation:
Keywords: Pharmacones clathration, Nifedipine, Glycyrrhizic acid, Calcium channels
Abstract: The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.
Export Options
About this article
Cite this article as:
Tolstikova G. T., Bryzgalov O. A., Sorokina V. I., Hvostov V. M., Ratushnyak S. A., Zapara A. T. and Simonova G. O., Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077453
DOI https://dx.doi.org/10.2174/157018007780077453 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Effects of Drugs Used in Anaesthesia on Platelet Membrane Receptors and on Platelet Function
Current Drug Targets Inotropic Therapies in Asphyxiated Neonates: The Clinical and Laboratory Facts
Current Pediatric Reviews Polymorphism in Endothelin-1 Gene: An Overview
Current Clinical Pharmacology Angiotensin-(1-7): Blood, Heart, and Blood Vessels
Current Medicinal Chemistry - Cardiovascular & Hematological Agents The Use of Infliximab in Dermatology
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Management of Blood Pressure and Heart Rate in Patients with Acute Stroke
Current Pharmaceutical Design Artemia species: An Important Tool to Screen General Toxicity Samples
Current Pharmaceutical Design Patents in the Diagnosis and Therapy of Neurocardiogenic Syncope
Recent Patents on Cardiovascular Drug Discovery Melatonin, a Potential Therapeutic Agent for Smooth Muscle-Related Pathological Conditions and Aging
Current Medicinal Chemistry Neuroprotective Strategies in Glaucoma
Current Pharmaceutical Design The Role of IRE1 Signaling in the Central Nervous System Diseases
Current Neuropharmacology Melanocortins As Innovative Drugs for Ischemic Diseases and Neurodegenerative Disorders: Established Data and Perspectives
Current Medicinal Chemistry Pharmacological Targets for the Inhibition of Neurogenic Inflammation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Evaluating Drug Safety in Children and Adolescents with Bipolar Disorder
Current Drug Safety Prognostic Implications of Genetics in Cardiovascular Disease
Current Pharmacogenomics Anti-Ophidian Properties of Herbal Medicinal Plants: Could it be a Remedy for Snake Bite Envenomation?
Current Drug Discovery Technologies Monoclonal Antibody Therapy in Haematological Malignancies
Current Clinical Pharmacology Telomere/Telomerase System: A New Target of Statins Pleiotropic Effect?
Current Vascular Pharmacology Combinations of Renin-Angiotensin-Aldosterone System Antagonists:True Advantages?
Current Pharmaceutical Design Future Directions in the Treatment of Neuropathic Pain: A Review on Various Therapeutic Targets
CNS & Neurological Disorders - Drug Targets