Abstract
Chiral derivative 3 has been recognized as a precursor of enantiopure 2,3-disubstituted piperidines. A study concerning the chemoselective reduction, using BH3.Me2S, of highly functionalised compounds 6 and N-BOC aminoacid 12 is reported.
Keywords: Asymmetric synthesis, pipecolic acids, piperidines, phenylglycinol, aza-annelation
Letters in Organic Chemistry
Title: Enantioselective Synthesis of 2,3-Disubstituted Piperidines
Volume: 4 Issue: 1
Author(s): Michael Calosso, Mathieu Wagner, Thomas Gendrineau, Morgane Petit, Catherine Kadouri-Puchot and Luc Dechoux
Affiliation:
Keywords: Asymmetric synthesis, pipecolic acids, piperidines, phenylglycinol, aza-annelation
Abstract: Chiral derivative 3 has been recognized as a precursor of enantiopure 2,3-disubstituted piperidines. A study concerning the chemoselective reduction, using BH3.Me2S, of highly functionalised compounds 6 and N-BOC aminoacid 12 is reported.
Export Options
About this article
Cite this article as:
Calosso Michael, Wagner Mathieu, Gendrineau Thomas, Petit Morgane, Kadouri-Puchot Catherine and Dechoux Luc, Enantioselective Synthesis of 2,3-Disubstituted Piperidines, Letters in Organic Chemistry 2007; 4 (1) . https://dx.doi.org/10.2174/157017807780037487
DOI https://dx.doi.org/10.2174/157017807780037487 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Comparative Corrosion Study of a New Type of “Ni-Free” Alloy for Decorative Applications
Recent Patents on Corrosion Science (Discontinued) The Role of Transforming Growth Factor-β1 Gene Polymorphism and Its Serum Levels in Hashimoto’s Thyroiditis
Current Pharmaceutical Biotechnology Autoantibodies for Cardiac Channels and Sudden Cardiac Death and its Relationship to Autoimmune Disorders
Current Cardiology Reviews Subject Index To Volume 2
Current Drug Metabolism Ginsenoside Rb1 Suppresses AOM/DSS-induced Colon Carcinogenesis
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in the Imaging of Programmed Cell Death
Current Pharmaceutical Design Persistent Allergic Minimum Phlogosis as Mechanistic Link Between Recurrent Respiratory Infections and Atopy: A Single Center Pilot Study
Current Respiratory Medicine Reviews Genetic and Epigenetic Drug Targets in Myelodysplastic Syndromes
Current Pharmaceutical Design The Modulating Effects of Endogenous Substances on Drug Metabolising Enzymes and Implications for Inter-Individual Variability and Quantitative Prediction
Current Drug Metabolism Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases
Current Medicinal Chemistry Therapeutic Potential of Poncirin Against Numerous Human Health Complications: Medicinal Uses and Therapeutic Benefit of an Active Principle of Citrus Species
Endocrine, Metabolic & Immune Disorders - Drug Targets Natural Cures for Type 1 Diabetes: A Review of Phytochemicals, Biological Actions, and Clinical Potential
Current Medicinal Chemistry Molecular Docking Simulations as a Prominent Tool to Envisage the Preformulation Perspectives of Oral Hypoglycaemic Agents with β-cyclodextrin
Letters in Drug Design & Discovery Do Rheumatoid Arthritis Patients Rate their Health Status Different than their Caregivers?
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Targeting Platelet-Neutrophil Interactions in Giant-Cell Arteritis
Current Pharmaceutical Design Inhaled Biologics: From Preclinical to Product Approval
Current Pharmaceutical Design Editorial (Thematic Issue: Immune Modulation)
Current Pharmaceutical Design Viral Correlates of HIV-1 Disease
Current HIV Research Cancer Stem Cells: The Emerging Challenge of Drug Targeting
Current Medicinal Chemistry Design, Synthesis and Pharmacological Evaluation of Some Novel Tetrahydrocarbazoles as Potential COX-2 Inhibitors
Letters in Drug Design & Discovery