Abstract
Urinary tract infection, one of the commonest bacterial diseases in children, carries a substantial risk of serious complications. Amongst them, renal scarring and recurrent infections seem to be the most important. In this review, we analyze the pathogenesis of urinary tract infection in order to identify those children who run the highest risk of unfavorable outcome. During infection, multiple bacterial and host factors interact with each other. Bacteria possess specific characteristics involved in the process of adhesion, invasion, survival and host damage during infection. Host factors also substantially participate in the pathogenesis of the disease. According to current knowledge, the specific host response appears to be the main factor predisposing for complications. However, prompt and adequate treatment of acute urinary tract infection remains the most important measure to prevent scarring. Dysfunctional holding and elimination of urine, on the other hand, mainly seem to influence the development of recurrent infection. Despite intensive research for many years, urinary tract infections are still a challenge for patients and health care professionals.
Keywords: UTI, E. coli, renal scarring, recurrent infections
Current Pediatric Reviews
Title: Urinary Tract Infection. Why Do Some Children Get Complications, While Others Dont?
Volume: 3 Issue: 1
Author(s): Milan Chromek and Annelie Brauner
Affiliation:
Keywords: UTI, E. coli, renal scarring, recurrent infections
Abstract: Urinary tract infection, one of the commonest bacterial diseases in children, carries a substantial risk of serious complications. Amongst them, renal scarring and recurrent infections seem to be the most important. In this review, we analyze the pathogenesis of urinary tract infection in order to identify those children who run the highest risk of unfavorable outcome. During infection, multiple bacterial and host factors interact with each other. Bacteria possess specific characteristics involved in the process of adhesion, invasion, survival and host damage during infection. Host factors also substantially participate in the pathogenesis of the disease. According to current knowledge, the specific host response appears to be the main factor predisposing for complications. However, prompt and adequate treatment of acute urinary tract infection remains the most important measure to prevent scarring. Dysfunctional holding and elimination of urine, on the other hand, mainly seem to influence the development of recurrent infection. Despite intensive research for many years, urinary tract infections are still a challenge for patients and health care professionals.
Export Options
About this article
Cite this article as:
Chromek Milan and Brauner Annelie, Urinary Tract Infection. Why Do Some Children Get Complications, While Others Dont?, Current Pediatric Reviews 2007; 3 (1) . https://dx.doi.org/10.2174/157339607779941705
DOI https://dx.doi.org/10.2174/157339607779941705 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Congenital Cytomegalovirus Infection: Molecular Mechanisms Mediating Viral Pathogenesis
Infectious Disorders - Drug Targets Novel Therapeutic Approaches to Autoimmune Demyelinating Disorders
Current Pharmaceutical Design Development of Nucleic Acid Drugs for Neurological Disorders
Current Topics in Medicinal Chemistry Editorial [Hot Topic:Avian and Pandemic Influenza Cytokine Storm, Inflammation,Tissue and Therapeutic Opportunities (Guest Editor: Jonathan P. Wong)]
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Sex Steroid Hormones, Cardiovascular Diseases and The Metabolic Syndrome
Cardiovascular & Hematological Agents in Medicinal Chemistry mTOR Inhibitors in Tuberous Sclerosis Complex
Current Neuropharmacology Role of Platelets in Angiogenesis in Health and Disease
Current Angiogenesis (Discontinued) Emerging Drug Therapies and Site-Specific Interventions for Autoimmune Hepatitis
Medicinal Chemistry Reviews - Online (Discontinued) BX471: A CCR1 Antagonist with Anti-Inflammatory Activity in Man
Mini-Reviews in Medicinal Chemistry Macrocyclic Lactones and Cellular Transport-Related Drug Interactions: A Perspective from In Vitro Assays to Nematode Control in the Field
Current Pharmaceutical Biotechnology Editorial: [Hot Topic: Primary Sjogren’s Syndrome Research and Therapy: Has a New Dawn Arrived?]
Current Pharmaceutical Biotechnology The ModifiedGlasgow Prognostic Score and Survival in Colorectal Cancer: A Pooled Analysis of the Literature
Reviews on Recent Clinical Trials Oral Angiotensin-(1-7) Peptide Modulates Intestinal Microbiota Improving Metabolic Profile in Obese Mice
Protein & Peptide Letters Development and Evaluation of Topical Nanoemulgel Formulation of Tazarotene for Effective Treatment of Excision Wounds
Current Nanomedicine Meet Our Editorial Board Member
Current Topics in Medicinal Chemistry Safflor Protected Rat Cerebral Ischemia-Reperfusion Injury Through Inhibiting the Expression of NF-kB and IL-1β
Neuroscience and Biomedical Engineering (Discontinued) Phenotypic Alteration of Bone Marrow HSC and Microenvironmental Association in Experimentally Induced Leukemia
Current Stem Cell Research & Therapy Impact of Ultrasound Contrast Agents in Echocardiographic Assessment of Ischemic Heart Disease
Recent Patents on Cardiovascular Drug Discovery BACE1 Structure and Function in Health and Alzheimers Disease
Current Alzheimer Research M1 Agonists as a Potential Disease-Modifying Therapy for Alzheimers Disease
Current Alzheimer Research