Abstract
Accumulating evidence has confirmed the existence and functional significance of GPCR and other types of receptor homodimers and heterodimers. However, many aspects of the biology and pharmacology of the dimerization process remain unclear. Several crystal structures of the dimerized proteins or protein-ligand complex have provided useful insights to the understanding of such process. As a common phenomenon of most receptors, homodimerization and heterodimerization have added a new dimension to characterize the receptor different from the traditional way, and open a new avenue to rational drug design and discovery.
Keywords: Homodimer, heterodimer, monomer, oligomerization, bivalent ligand, GPCR
Current Topics in Medicinal Chemistry
Title: Receptor Dimerization - Rationale for the Design of Bivalent Ligands
Volume: 7 Issue: 4
Author(s): Ao Zhang, Zhili Liu and Ying Kan
Affiliation:
Keywords: Homodimer, heterodimer, monomer, oligomerization, bivalent ligand, GPCR
Abstract: Accumulating evidence has confirmed the existence and functional significance of GPCR and other types of receptor homodimers and heterodimers. However, many aspects of the biology and pharmacology of the dimerization process remain unclear. Several crystal structures of the dimerized proteins or protein-ligand complex have provided useful insights to the understanding of such process. As a common phenomenon of most receptors, homodimerization and heterodimerization have added a new dimension to characterize the receptor different from the traditional way, and open a new avenue to rational drug design and discovery.
Export Options
About this article
Cite this article as:
Zhang Ao, Liu Zhili and Kan Ying, Receptor Dimerization - Rationale for the Design of Bivalent Ligands, Current Topics in Medicinal Chemistry 2007; 7 (4) . https://dx.doi.org/10.2174/156802607779941279
DOI https://dx.doi.org/10.2174/156802607779941279 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Chemoprevention of Colorectal Cancer: Progress or Pipedream?
Current Cancer Therapy Reviews Extracellular Citrate in Health and Disease
Current Molecular Medicine The Role of ER Stress-Induced Apoptosis in Neurodegeneration
Current Alzheimer Research Viral and Non-Viral Approaches for Transient Delivery of mRNA and Proteins
Current Gene Therapy An Expanding Appreciation of the Role Chemokine Receptors Play in Cancer Progression
Current Pharmaceutical Design A Novel Monoclonal Antibody Against the C-terminus of β-Tubulin Recognizes Endocytic Organelles in Trypanosoma cruzi
Protein & Peptide Letters Nanotechnology and Alzheimer's Disease: What has been Done and What to Do'
Current Medicinal Chemistry Regulation and Function of DNA and Histone Methylations
Current Pharmaceutical Design Cardiovascular Effects of Neuregulin-1/ErbB Signaling: Role in Vascular Signaling and Angiogenesis
Current Pharmaceutical Design Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective
Current Alzheimer Research Methylenetetrahydrofolate Reductase (MTHFR): A Novel Target for Cancer Therapy
Current Pharmaceutical Design Cellular and Biochemical Actions of Melatonin which Protect Against Free Radicals: Role in Neurodegenerative Disorders
Current Neuropharmacology Image-Guided Nanoparticle-Based siRNA Delivery for Cancer Therapy
Current Pharmaceutical Design Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors
Current Medicinal Chemistry Potential Targets for the Development of Novel Antidepressants: Future Perspectives
CNS & Neurological Disorders - Drug Targets Actions of Melatonin, Its Structural and Functional Analogs in the Central Nervous System and the Significance of Metabolism
Central Nervous System Agents in Medicinal Chemistry Assessing Activation States in Microglia
CNS & Neurological Disorders - Drug Targets GPER and ER: Estrogen Receptors with Distinct Biological Roles in Breast Cancer
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Can Dietary Antioxidants Reduce the Incidence of Brain Tumors?
Current Drug Metabolism Review: The Role of Radiolabeled DOTA-Conjugated Peptides for Imaging and Treatment of Childhood Neuroblastoma
Current Radiopharmaceuticals