Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants

Title: Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants

Volume: 7 Issue: 2

Author(s): Quan Liu, Fang Xie, Raj Rolston, Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Mark A. Smith and George Perry

Affiliation:

Keywords: Antioxidant, calorie restriction, estrogen, free radical, glutathione, oxidation, oxidative stress, sirtuin, therapy, vitamin C

Abstract: There is considerable evidence showing that oxidative damage is one of the earliest neuronal and pathological changes of Alzheimer disease and many, if not all, of the etiological and pathological causes of the disease are related, directly or indirectly, to free radical production and oxidative damage. Here we summarize the current body of knowledge suggestive that oxidative damage is, if not the key factor, certainly a major factor in Alzheimer disease. As such, therapeutic modalities encompassing antioxidants may be an effective approach to the treatment of neurodegenerative diseases and delay the aging process.

Cite this article as:

Liu Quan, Xie Fang, Rolston Raj, Moreira I. Paula, Nunomura Akihiko, Zhu Xiongwei, Smith A. Mark and Perry George, Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants, Mini-Reviews in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/138955707779802552