Natural and Synthetic Cholera Toxin Antagonists

Title: Natural and Synthetic Cholera Toxin Antagonists

Volume: 7 Issue: 2

Author(s): I. A. Velter, M. Politi, C. Podlipnik and F. Nicotra

Affiliation:

Keywords: Cholera toxin, ganglioside GM1, catechins, galactose, multivalency

Abstract: Cholera Toxin (CT) recognizes the cell membrane through specific interactions with ganglioside GM1. Recent structural elucidation of the CT/GM1 complex has allowed the rational design of artificial receptors for the toxin, which could function as anti-cholera drugs. The efforts towards the rational design of Cholera Toxin inhibitors will be presented.

Cite this article as:

Velter A. I., Politi M., Podlipnik C. and Nicotra F., Natural and Synthetic Cholera Toxin Antagonists, Mini-Reviews in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/138955707779802589