Synthetic Derivatives of Osthole for the Prevention of Hepatitis

Title: Synthetic Derivatives of Osthole for the Prevention of Hepatitis

Volume: 3 Issue: 1

Author(s): Toshihiro Okamoto, Tadashi Kobayashi and Shinic hi Yoshida

Affiliation:

Keywords: Osthole Skeleton, nitrocoumarin, allyloxycoumarin, nitroquinoline, Apoptosis

Abstract: Prevention of hepatitis is a worldwide issue. For most patients with liver disease, hepatoprotective drugs are required. But there are only a few hepatoprotective drugs available. Osthole is a coumarin compound and protects the liver from hepatitis by preventing the development of apoptosis. However, osthole exhibits low water solubility, and some structural modifications are required for sufficient hepatoprotection upon oral administration. We synthesized 28 osthole derivatives, and then studied their effects by using mice concanavalin A (Con A) -induced hepatitis. The osthole derivatives No.1, 9 and 19 showed stronger inhibition of Con A-induced elevation of plasma alanine aminotransferase (ALT). Oral administration of osthole at the dose of 100 mg/kg (n=10) inhibited 38.0 % of the Con A-induced elevation of plasma ALT. In contrast, oral administration of Nos. 1, 9 and 19 at the dose of 100 mg/kg (n=5) caused 68.7%, 62.5% and 88.3% inhibition of the Con A-induced elevation of plasma ALT, respectively. These synthetic osthole derivatives could contribute to the development of hepatoprotective drugs effective for various types of liver diseases on oral administration.

Cite this article as:

Okamoto Toshihiro, Kobayashi Tadashi and hi Yoshida Shinic, Synthetic Derivatives of Osthole for the Prevention of Hepatitis, Medicinal Chemistry 2007; 3 (1) . https://dx.doi.org/10.2174/157340607779317607