Binding Sites on Laminin Receptors as Components for Antibiotics

Nahoko      Kobayashi; Tetsuhiko      Yoshida

Abstract

Bacteria use the receptor-adhesion-like interaction between laminin and the laminin receptor in the process of infection. We determined that bacteria do not interact with the receptor-binding site on laminin which could be expected for the bacterial laminin receptor. Rather, binding occurs via the laminin-binding site on the 67-kDa laminin receptor, which has a function similar to the one the bacterial laminin receptor possesses. This finding has implications for the effective use of antimicrobial peptides.

Keywords: Laminin, laminin receptor, antimicrobial peptide, minimum inhibitory concentration (MIC), prion, binding site

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Protein & Peptide Letters

Title: Binding Sites on Laminin Receptors as Components for Antibiotics

Volume: 14 Issue: 1

Author(s): Nahoko Kobayashi and Tetsuhiko Yoshida

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Keywords: Laminin, laminin receptor, antimicrobial peptide, minimum inhibitory concentration (MIC), prion, binding site

Abstract: Bacteria use the receptor-adhesion-like interaction between laminin and the laminin receptor in the process of infection. We determined that bacteria do not interact with the receptor-binding site on laminin which could be expected for the bacterial laminin receptor. Rather, binding occurs via the laminin-binding site on the 67-kDa laminin receptor, which has a function similar to the one the bacterial laminin receptor possesses. This finding has implications for the effective use of antimicrobial peptides.

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Kobayashi Nahoko and Yoshida Tetsuhiko, Binding Sites on Laminin Receptors as Components for Antibiotics, Protein & Peptide Letters 2007; 14 (1) . https://dx.doi.org/10.2174/092986607779117290