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Current Stem Cell Research & Therapy


ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

The Role of Stroma in Hematopoiesis and Dendritic Cell Development

Author(s): Genevieve Despars, Jonathan Tan, Pravin Periasamy, Helen C. O'Neill and Helen C. O'Neill

Volume 2, Issue 1, 2007

Page: [23 - 29] Pages: 7

DOI: 10.2174/157488807779317017

Price: $65


Development of the immune system is depicted as a hierarchical process of differentiation from hematopoietic stem cells (HSC) to lineage-committed precursors, which further develop into mature immune cells. In the case of dendritic cell (DC) development, this linear precursor-progeny approach has led to a confused picture of relationships between various subsets of DC identifiable in vivo. A possible reconciliation of the diversity of DC precursors and DC subsets in vivo encompasses the role of the microenvironment in DC hematopoiesis. We propose here that various niches for DC hematopoiesis within lymphoid organs could account for the diversity of DC in vivo. A tridimensional space consisting of stromal cells which produce a range of membrane-bound and secreted molecules providing signals to DC progenitors would define these niches

Keywords: Niche, endothelial cells, hematopoiesis, dendritic cells

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